A powerful vehicle bomb has hit the diplomatic area of the Kabul.
The blast reportedly claimed the lives of at least 80 people and injured another 350.
Civilians are said to make up a large number of the casualties. The bomb, which struck near the German embassy in Zanbaq Square, was so strong it blew out windows and doors hundreds of meters away. It detonated in the diplomatic quarter at about 08:25 local time during rush hour.
Kabul police spokesman Basir Mujahid, told Reuters that the explosion had taken place close to the German embassy but added it was "hard to say what the exact target is." Since there are many other important buildings in the area, including the presidential palace and a number of embassies.
Improvized ambulances transported the wounded away from the scene, as frantic relatives gathered at the site to try to locate loved ones.
Images of the area showed dozens of charred vehicles among the more than 50 that were reportedly destroyed. Health ministry spokesman Ismael Kawoosi said: "They are still bringing bodies and wounded people to hospitals." The interior ministry has called on residents to donate blood, saying there was a "dire need."
Afghan President Ashraf Ghani said he "strongly condemned the cowardly attack in the holy month of Ramadan targeting innocent civilians in their daily life".
Indian PM Narendra Modi also tweeted his condemnation, saying: "Our thoughts are with the families of the deceased & prayers with the injured."
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The Taliban and the Islamic State are the main suspects. However, the Taliban promptly issued a statement denying any involvement, while the Islamic State remains mum.
The IS claimed last month's suicide bomb attack on the Nato convoy near the U.S. embassy, which killed eight civilians.
Spokesman Zabihullah Mujahid said the Taliban condemned untargeted attacks that caused civilian casualties. Their spring offensive detailed that their main focus would be foreign forces, targeting them with a mix of conventional, guerrilla, insider and suicide attacks.
The U.S. has approximately 8,400 troops in Afghanistan and 5,000 Nato allies.
Recent Kabul attacks
8 March 2017 - More than 30 people killed after attackers dressed as doctors stormed Sardar Daud Khan military hospital
21 Nov 2016 - At least 27 dead in a suicide bomb attack on Baqir ul Olum mosque during a Shia ceremony
23 July 2016 - At least 80 people killed in twin bomb blasts targeting a rally by the Shia Hazara minority in Deh Mazang square
19 Apr 2016 - At least 28 dead in a huge explosion close to the Afghan defence ministry building
1 Feb 2016 - 20 killed in a suicide bomb attack at police headquarters
7 Aug 2015 - At least 35 people dead in separate bomb attacks across the capital